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Literature summary for 3.5.4.16 extracted from

  • Du, J.; Xu, H.; Wei, N.; Wakim, B.; Halligan, B.; Pritchard, K.A.; Shi, Y.
    Identification of proteins interacting with GTP cyclohydrolase I (2009), Biochem. Biophys. Res. Commun., 385, 143-147.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-
membrane
-
Rattus norvegicus 16020
-
nucleus
-
Rattus norvegicus 5634
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GCH-1 interacts with many signal transduction proteins such as receptors (NKG2-A/B-actvating NK receptor and latrophilin-2), kinase (Death-associated protein kinase 3), adaptors (Rho-GTPase-activating protein 7 and Rho-guanine nucleotide exchange factor 3) and transcriptional factors (ATF-6 alpha and interferon regulatory factor 1) Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
GCH-1
-
Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus tetracycline stimulation substantially increases GCH-1 activity about 20fold up

General Information

General Information Comment Organism
physiological function GCH-1 is a key enzyme in de novo tetrahydrobiopterin biosynthesis. GCH-1 is critical for maintaining coupled NOS activity and aromatic amino acid hydroxylation, pain sensitivity and chronicity, and immune responses Rattus norvegicus