Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cells | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
membrane | - |
Rattus norvegicus | 16020 | - |
nucleus | - |
Rattus norvegicus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | GCH-1 interacts with many signal transduction proteins such as receptors (NKG2-A/B-actvating NK receptor and latrophilin-2), kinase (Death-associated protein kinase 3), adaptors (Rho-GTPase-activating protein 7 and Rho-guanine nucleotide exchange factor 3) and transcriptional factors (ATF-6 alpha and interferon regulatory factor 1) | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCH-1 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | tetracycline stimulation substantially increases GCH-1 activity about 20fold | up |
General Information | Comment | Organism |
---|---|---|
physiological function | GCH-1 is a key enzyme in de novo tetrahydrobiopterin biosynthesis. GCH-1 is critical for maintaining coupled NOS activity and aromatic amino acid hydroxylation, pain sensitivity and chronicity, and immune responses | Rattus norvegicus |