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Literature summary for 3.5.4.16 extracted from

  • Peterson, T.E.; dUscio, L.V.; Cao, S.; Wang, X.L.; Katusic, Z.S.
    Guanosine triphosphate cyclohydrolase I expression and enzymatic activity are present in caveolae of endothelial cells (2009), Hypertension, 53, 189-195.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.16

Inhibitors

Inhibitors Comment Organism Structure
caveolin-1 overexpression of caveolin-1 inhibits GTPCH I activity Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane GTPCH I is also co-localized with caveolin-1 to caveolar membrane microdomains of endothelial cells Mus musculus 16020
-
nucleus GTPCH I staining is localized to perinuclear regions of the cell Mus musculus 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
 SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus tetrahydrobiopterin production by GTPCH I occurs in close proximity to endothelial nitric oxide synthase ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Mus musculus
-
endothelial cell
-
 Mus musculus
-
lung
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Mus musculus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
additional information tetrahydrobiopterin production by GTPCH I occurs in close proximity to endothelial nitric oxide synthase Mus musculus ?
-
 ?

Synonyms

Synonyms Comment Organism
GTPCH I
-
 Mus musculus
guanosine triphosphate cyclohydrolase I
-
 Mus musculus