Organism | UniProt | Comment | Textmining |
---|---|---|---|
Sus scrofa | - |
pigs express four different A3 mRNAs encoding poA3Z2, poA3Z3, and by read-through transcription and alternatively splicing poA3Z2-Z3 and poA3Z2-Z3 splice variant A (SVA) | - |
Synonyms | Comment | Organism |
---|---|---|
APOBEC3 | - |
Sus scrofa |
General Information | Comment | Organism |
---|---|---|
physiological function | porcine A3 is tested toward their antiretroviral activity against porcine endogenous retrovirus (PERV) and murine leukemia virus (MuLV) using novel single-round reporter viruses. The porcine A3Z2, A3Z3 and A3Z2-Z3 mRNAs are packaged into PERV particles and inhibit PERV replication in a dose-dependent manner. The antiretroviral effect correlate with editing by the porcine A3s with a trinucleotide preference for 5' TGC for A3Z2 and A3Z2-Z3 and 5' CAC for A3Z3 | Sus scrofa |