Cloned (Comment) | Organism |
---|---|
expression of the chimeric mutant cytosine deaminase/uracil phosphoribosyl transferase in Plasmodium falciparum, negative selection with 5-fluorocytosine | Saccharomyces cerevisiae |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of a chimeric bifuntional enzyme comprising cytosine deaminase and uracil phosphoribosyl transferase activities, overview | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorocytosine + H2O | reaction of cytosine deaminase, the uracil phosphoribosyl transferase part in a chimeric bifunctional enzyme converts 5-fluorouracil into 5-fluoro-UMP, which is a precursor for the cell toxic 5-fluoro-UTP, used for negative selection of transgenic Plasmodium falciparum parasites | Saccharomyces cerevisiae | 5-fluorouracil + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cytosine deaminase | - |
Saccharomyces cerevisiae |