Application | Comment | Organism |
---|---|---|
medicine | the enzyme is useful in treatment of human ovarian cancer by genetic prodrug activation therapy, overview | Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of and transfection with vectors encoding Escherichia coli cytosine deaminase and herpes simplex virus thymidine kinase leads to greater cell death in procaspase-3-expressing clones of 3AO cells, ovarian cancer cells than in control cells after treatment with ganciclovir or 5-fluorocytosine, as well as more rapid activation of caspase-3 and more rapid cleavage of poly (adenosine diphosphate-ribose) polymerase, overview | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine + H2O | Escherichia coli | - |
uracil + NH3 | - |
? | |
additional information | Escherichia coli | the enzyme is useful in treatment of human ovarian cancer by genetic prodrug activation therapy with procaspase-3 co-expression improving the method, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorocytosine + H2O | - |
Escherichia coli | 5-fluorouracil + NH3 | - |
? | |
cytosine + H2O | - |
Escherichia coli | uracil + NH3 | - |
? | |
additional information | the enzyme is useful in treatment of human ovarian cancer by genetic prodrug activation therapy with procaspase-3 co-expression improving the method, overview | Escherichia coli | ? | - |
? |