Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.4.1 extracted from

  • Erbs, P.; Exinger, F.; Jund, R.
    Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans (1997), Curr. Genet., 31, 1-6.
    View publication on PubMed
Search for more literature for 3.5.4.1

Application

Application Comment Organism
medicine
-
 Escherichia coli
medicine facilitate pharmacological advance, possible application is transfer of FCY1 and FCA1 to mammalian cells naturally lacking enzyme activity, these genes should confer lethal sensitivity to 5-fluorocytosine Saccharomyces cerevisiae
medicine facilitate pharmacological advance, possible application is transfer of FCY1 and FCA1 to mammalian cells naturally lacking enzyme activity, these genes should confer lethal sensitivity to 5-fluorocytosine Candida albicans

Cloned(Commentary)

Cloned (Comment) Organism
codBA operon encoding cytosine permease and cytosine deaminase cloned Escherichia coli
FCA1 gene cloned from a genomic Candida albicans gene bank, constructed in the low-copy vector pMK122 Candida albicans
FCY1 gene cloned and characterized Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine + H2O Salmonella enterica subsp. enterica serovar Typhimurium
-
 uracil + NH3
-
 ?
cytosine + H2O Escherichia coli
-
 uracil + NH3
-
 ?
cytosine + H2O Saccharomyces cerevisiae
-
 uracil + NH3
-
 ?
cytosine + H2O Candida albicans
-
 uracil + NH3
-
 ?
cytosine + H2O Aspergillus fumigatus
-
 uracil + NH3
-
 ?
cytosine + H2O Aspergillus fumigatus IFO5840
-
 uracil + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus
-
 IFO5840
-
Aspergillus fumigatus IFO5840
-
 IFO5840
-
Candida albicans
-
-
-
Escherichia coli
-
-
-
Saccharomyces cerevisiae
-
-
-
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine + H2O
-
 Salmonella enterica subsp. enterica serovar Typhimurium uracil + NH3
-
 ?
cytosine + H2O
-
 Escherichia coli uracil + NH3
-
 ?
cytosine + H2O
-
 Saccharomyces cerevisiae uracil + NH3
-
 ?
cytosine + H2O
-
 Candida albicans uracil + NH3
-
 ?
cytosine + H2O
-
 Aspergillus fumigatus uracil + NH3
-
 ?
cytosine + H2O
-
 Aspergillus fumigatus IFO5840 uracil + NH3
-
 ?