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Literature summary for 3.5.4.1 extracted from

  • Austin, E.A.; Huber, B.E.
    A first step in the development of gene therapy for colorectal carcinoma: Clonig, sequencing, and expression of Escherichia coli cytosine deaminase (1992), Mol. Pharmacol., 43, 380-387.
    View publication on PubMed

Application

Application Comment Organism
medicine gene therapy for treatment of primary and metastatic tumors in the liver, development of gene therapy treatment for metastatic colorectal carcinoma Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
CD gene codA cloned into mammalian expression vector, WiDr cells, a human CRC cell line transformed Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ catalytically essential divalent metal ion Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
52000
-
4 * 52000, SDS-PAGE Escherichia coli
210000
-
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine + H2O Escherichia coli
-
uracil + NH3
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
Chi 82
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorocytosine + H2O
-
Escherichia coli 5-fluorouracil + NH3
-
?
cytosine + H2O
-
Escherichia coli uracil + NH3
-
?

Subunits

Subunits Comment Organism
tetramer 4 * 52000, SDS-PAGE Escherichia coli

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
thermostable between pH 7-9 Escherichia coli