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Literature summary for 3.5.3.15 extracted from

  • Abdullah, S.N.; Farmer, E.A.; Spargo, L.; Logan, R.; Gully, N.
    Porphyromonas gingivalis peptidylarginine deiminase substrate specificity (2013), Anaerobe, 23, 102-108.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information 1 mM tosyl phenylalanyl chloromethyl ketone and 0.043 mM leupeptin do not inhibit enzyme activity Porphyromonas gingivalis

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface 90% of enzyme activity is cell surface associated Porphyromonas gingivalis 9986
-
cytoplasm 10% of enzyme activity is cytoplasn associated Porphyromonas gingivalis 5737
-

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-
Porphyromonas gingivalis W50
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
agmatine + H2O 5.4% activity compared to L-arginine Porphyromonas gingivalis ? + NH3
-
?
fibrin L-arginine + H2O
-
Porphyromonas gingivalis fibrin L-citrulline + NH3
-
?
fibrin L-arginine + H2O
-
Porphyromonas gingivalis W50 fibrin L-citrulline + NH3
-
?
Gly-Gly-L-Arg + H2O 88% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis Gly-Gly-L-Cit + NH3
-
?
Gly-Gly-L-Arg + H2O 88% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis W50 Gly-Gly-L-Cit + NH3
-
?
Gly-L-Arg + H2O 130% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis Gly-L-Cit + NH3
-
?
Gly-L-Arg + H2O 130% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis W50 Gly-L-Cit + NH3
-
?
human vimentin L-arginine + H2O
-
Porphyromonas gingivalis human vimentin L-citrulline + NH3
-
?
L-Arg-Gly + H2O 75% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis L-Cit-Gly + NH3
-
?
L-Arg-Gly-Gly + H2O 66% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis L-Cit-Gly-Gly + NH3
-
?
L-arginine + H2O 28% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis L-citrulline + NH3
-
?
L-arginine + H2O 28% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis W50 L-citrulline + NH3
-
?
L-canavanine + H2O 0.3% activity compared to L-arginine Porphyromonas gingivalis ? + NH3
-
?
L-homoarginine + H2O 0.3% activity compared to L-arginine Porphyromonas gingivalis ? + NH3
-
?
L-Leu-Trp-Met-Arg + H2O 45% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis L-Leu-Trp-Met-Cit + NH3
-
?
L-Met-Arg-Phe + H2O the substrate shows fastest rate of citrullination with 158% activity compared to Nalpha-benzoyl-L-arginine ethyl ester Porphyromonas gingivalis L-Met-Cit-Phe + NH3
-
?
L-octopine + H2O 16.7% activity compared to L-arginine Porphyromonas gingivalis ? + NH3
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O 100% activity Porphyromonas gingivalis Nalpha-benzoyl-L-citrulline ethyl ester + NH3
-
?
Nalpha-benzoyl-L-arginine ethyl ester + H2O 100% activity Porphyromonas gingivalis W50 Nalpha-benzoyl-L-citrulline ethyl ester + NH3
-
?
yeast enolase L-arginine + H2O
-
Porphyromonas gingivalis yeast enolase L-citrulline + NH3
-
?

Synonyms

Synonyms Comment Organism
PAD
-
Porphyromonas gingivalis
peptidylarginine deiminase
-
Porphyromonas gingivalis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
60
-
enzyme activity decreases by 13% following exposure of cells to 60°C for 10 min Porphyromonas gingivalis

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8
-
Porphyromonas gingivalis

General Information

General Information Comment Organism
physiological function enzyme's presence in inflamed tissue may promote autoimmune reactions by creation of altered host epitopes Porphyromonas gingivalis