KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.35 | - |
Nalpha-benzoyl-L-arginine ethyl ester | pH 7.5, 68°C | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
PAD is purified in 12.5% yield and 137fold from bovine brain by chromatography on diethylaminoethyl (DEAE)-sephacel | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Bos taurus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
59 | - |
pH 7.5, 68°C | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | PAD II not only binds with the beta-amyloid peptides Abeta1-40, Abeta22-35, Abeta17-28,Abeta25-35 and Abeta32-35 but assists in the proteolytic degradation of these peptides with the concomitant formation of insoluble fibrils | Bos taurus | ? | - |
? | |
Nalpha-benzoyl-L-arginine ethyl ester + H2O | - |
Bos taurus | Nalpha-benzoyl-L-citrulline ethyl ester + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAD II | - |
Bos taurus |
peptidylarginine deiminase | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
68 | - |
- |
Bos taurus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
68 | - |
enzyme loses 50% of its activity within 38 min | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
- |
Bos taurus |