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Literature summary for 3.5.3.1 extracted from
- Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity (2009), Int. J. Parasitol., 39, 267-279.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli strain DH5alpha | Schistosoma mansoni |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-cysteine | strongly blocked SmARG-activity | Schistosoma mansoni |  |
| L-histidine | strongly blocked SmARG-activity | Schistosoma mansoni | |
| L-ornithine | moderately inhibitory | Schistosoma mansoni | |
| additional information | L-lysine and diaminopimelic acid failed to block SmARG activity | Schistosoma mansoni | |
| NOHA | - |
Schistosoma mansoni | |
| Nomega-hydroxy-nor-L-arginine | norNOHA | Schistosoma mansoni | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 17 | - |
L-arginine | pH 10, 37°C | Schistosoma mansoni | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | - |
Schistosoma mansoni | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
6 * 40000, SDS-PAGE | Schistosoma mansoni |
| 240000 | - |
gel filtration | Schistosoma mansoni |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Schistosoma mansoni | infection of mice with Schistosoma mansoni cercariae elevates arginase activity | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Schistosoma mansoni | Q6TA39 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Schistosoma mansoni |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 669 | - |
- |
Schistosoma mansoni |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-arginine + H2O | - |
Schistosoma mansoni | L-ornithine + urea | - |
? | |
| additional information | infection of mice with Schistosoma mansoni cercariae elevates arginase activity | Schistosoma mansoni | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | 6 * 40000, SDS-PAGE | Schistosoma mansoni |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| arginase | - |
Schistosoma mansoni |
| SmARG | - |
Schistosoma mansoni |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Schistosoma mansoni |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 537 | - |
L-arginine | pH 10, 37°C | Schistosoma mansoni | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 10 | - |
assay at | Schistosoma mansoni |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.9 | - |
L-ornithine | pH 10, 37°C | Schistosoma mansoni | |
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Release 2023.1 (January 2023)
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