Literature summary for 3.5.3.1 extracted from

Dowling, D.P.; Di Costanzo, L.; Gennadios, H.A.; Christianson, D.W.
Evolution of the arginase fold and functional diversity (2008), Cell. Mol. Life Sci., 65, 2039-2055.

Search for more literature for 3.5.3.1

Inhibitors

Inhibitors	Comment	Organism	Structure
(S)-2-amino-7-oxoheptanoic acid	-	Homo sapiens
(S)-2-amino-7-oxoheptanoic acid	-	Rattus norvegicus
additional information	arginase activity functionally inhibits nitric oxide synthase by depleting the substrate pool of L-arginine, and nitric oxide synthase activity potentially inhibits arginase by generating and releasing small amounts of the intermediate N-hydroxy-L-arginine, a competitive inhibitor of arginase, and also by generating nitric oxide itself, which can nitrosylate cysteine residues of human arginase I to modulate its activity; arginase activity functionally inhibits nitric oxide synthase by depleting the substrate pool of L-arginine, and nitric oxide synthase activity potentially inhibits arginase by generating and releasing small amounts of the intermediate N-hydroxy-L-arginine, a competitive inhibitor of arginase, and also by generating nitric oxide itself, which can nitrosylate cysteine residues of human arginase I to modulate its activity	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
1	-	L-arginine	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-
cytosol	-	Rattus norvegicus	5829	-
mitochondrion	-	Homo sapiens	5739	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mn2+	manganese metalloenzyme	Homo sapiens
Mn2+	manganese metalloenzyme, Mn2+-Mn2+ cluster in the active site of each monomer	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	hereditary defects in arginase compromise structure and catalysis, which results in an accumulation of arginine in the blood known as hyperarginemia. Arginase deficiency can also result in the accumulation of nitrogen in the form of ammonia, which results in hyperammonemia	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P05089	-	-
Homo sapiens	P78540	-	-
Rattus norvegicus	P07824	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-
liver	-	Rattus norvegicus	-
additional information	nonhepatic tissue	Homo sapiens	-
vascular smooth muscle cell	-	Homo sapiens	-
vascular smooth muscle cell	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-arginine + H2O	-	Homo sapiens	L-ornithine + urea	-	?
L-arginine + H2O	-	Rattus norvegicus	L-ornithine + urea	-	?
additional information	hereditary defects in arginase compromise structure and catalysis, which results in an accumulation of arginine in the blood known as hyperarginemia. Arginase deficiency can also result in the accumulation of nitrogen in the form of ammonia, which results in hyperammonemia	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
trimer	-	Homo sapiens
trimer	trimeric quaternary structure in which each monomer adopts an alpha/betafold consisting of a central parallel eight-stranded beta-sheet flanked on both sides by several alpha-helices	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
arginase	-	Homo sapiens
arginase	-	Rattus norvegicus
arginase I	-	Homo sapiens
arginase I	-	Rattus norvegicus
arginase II	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.06	-	(S)-2-amino-7-oxoheptanoic acid	-	Rattus norvegicus

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Release 2023.1 (January 2023)