Literature summary for 3.5.3.1 extracted from

Morris, C.R.; Kato, G.J.; Poijakovic, M.; Wang, X.; Blackwelder, W.C.; Sachdev, V.; Hazen, S.L.; Vichinsky, E.P.; Morris, S.M.; Gladwin, M.T.
Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease (2005), J. Am. Med. Assoc., 294, 81-90.

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Application

Application	Comment	Organism
medicine	plasma arginase activity is significantly elevated in patients with sickle cell disease, with highest activity found in patients with secondary pulmonary hypertension. Arginase activity correlates with the arginine-ornithine ratio, and lower ratios are associated with greater severity of pulmonary hypertension and with mortality. Increased plasma enzyme activity is correlated with increased intravascular hemolytic rate and, to a lesser extent, with markers of inflammation and soluble adhesion molecule levels	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	outpatients with sickle cell disease	-

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Release 2023.1 (January 2023)