Activating Compound | Comment | Organism | Structure |
---|---|---|---|
IL-4 | interleukin IL-4, up to 16-fold stimulation of enzyme activity in RAW-264.7 cell, in combinantion with rolipram additional activation. No stimulation of enzyme in alveolar macrophages by IL-4 alone, but increase of stimulation by forskolin and 3-isobutyl-1-methylxanthine, IBMX, in presence of IL-4 | Homo sapiens | |
additional information | rolipram increases stimulation by interleukin IL-4 and transforming growth factor beta | Homo sapiens | |
TGF-beta | transforming growth factor, up to 5-fold stimulation, further stimulation in combination with rolipram | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | agents that elevate cAMP level significantly enhance induction of enzyme by cytokines. Consequences of increased enzyme expression should be evaluated when phosphodiesterase inhibitors are used for treatment of inflammatory disorders in which IL-4 and/or TGF-beta predominate | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | alveolar macrophage | Homo sapiens | - |
RAW-264.7 cell | - |
Homo sapiens | - |