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Literature summary for 3.5.3.1 extracted from

  • Tormanen, C.D.
    Allosteric inhibition of rat liver and kidney arginase by copper and mercury ions (2001), J. Enzyme Inhib., 16, 443-449.
    View publication on PubMed
Search for more literature for 3.5.3.1

Inhibitors

Inhibitors Comment Organism Structure
Al3+ no inhibition of isozyme I, 33% inhibition of isozyme II Rattus norvegicus
Cd2+ 10% inhibition of isozyme I, 86% inhibition of isozyme II Rattus norvegicus
Cu2+ 56% inhibition of isozyme I, 69% inhibition of isozyme II, non-linear allosteric inhibition for isozymes I and II, inhibition is increased with isozyme I by preincubation with the metal ions, not with isozyme II Rattus norvegicus
Fe3+ 12% inhibition of isozyme I, 36% inhibition of isozyme II Rattus norvegicus
Hg2+ 80% inhibition of isozyme I, 96% inhibition of isozyme II, non-linear allosteric inhibition for isozymes I and II, inhibition is increased with isozyme I by preincubation with the metal ions, not with isozyme II Rattus norvegicus
additional information effect of preincubation of the isozymes with metal ions, overview Rattus norvegicus
Ni2+ no inhibition of isozyme I, 11% inhibition of isozyme II Rattus norvegicus
Pb2+ 74% inhibition of isozyme I, 92% inhibition of isozyme II Rattus norvegicus
Zn2+ 13% inhibition of isozyme I, 75% inhibition of isozyme II Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ activates isozyme II 1.46fold, no activation of isozyme I Rattus norvegicus
Mn2+ dependent on, manganese-metalloenzyme, activates isozyme I, slightly, and isozyme II Rattus norvegicus
additional information isozymes are not affected by Mg2+ and Ca2+ Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney isozyme II Rattus norvegicus
-
liver isozyme I Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
-
 Rattus norvegicus L-ornithine + urea
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information inhibition kinetics Rattus norvegicus