Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-((benzyloxycarbonylaminooxy)carbonyloxy)benzoic acid | o-aryloxycarbonyl hydroxamate, cephalothin as substrate, competitive inhibition, inhibits irreversibly | Enterobacter cloacae | |
benzyl (4-chlorophenoxy)carbonyloxycarbamate | o-aryloxycarbonyl hydroxamate, cephalothin as substrate, competitive inhibition, inhibits irreversibly | Enterobacter cloacae | |
benzyl (4-methoxyphenoxy)carbonyloxycarbamate | o-aryloxycarbonyl hydroxamate, cephalothin as substrate, competitive inhibition, inhibits irreversibly | Enterobacter cloacae | |
benzyl (4-nitrophenoxy)carbonyloxycarbamate | o-aryloxycarbonyl hydroxamate, cephalothin as substrate, competitive inhibition, inhibits irreversibly | Enterobacter cloacae | |
benzyl (naphthalen-2-yloxy)carbonyloxycarbamate | o-aryloxycarbonyl hydroxamate, cephalothin as substrate, competitive inhibition, inhibits irreversibly | Enterobacter cloacae | |
benzyl carbonylbis(oxy)dicarbamate | o-aryloxycarbonyl hydroxamate, cephalothin as substrate, competitive inhibition, inhibits irreversibly | Enterobacter cloacae | |
benzyl methoxycarbonyloxycarbamate | o-aryloxycarbonyl hydroxamate, cephalothin as substrate, competitive inhibition, inhibits irreversibly | Enterobacter cloacae | |
benzyl methyl(phenoxycarbonyloxy)carbamate | o-aryloxycarbonyl hydroxamate, cephalothin as substrate, competitive inhibition, inhibits slightly, 20fold less effectiv than benzyl phenoxycarbonyloxycarbamate | Enterobacter cloacae | |
benzyl phenoxycarbonothioyloxycarbamate | o-aryloxycarbonyl hydroxamate, cephalothin as substrate, competitive inhibition, inhibits slightly | Enterobacter cloacae | |
benzyl phenoxycarbonyloxycarbamate | o-aryloxycarbonyl hydroxamate, cephalothin as substrate, competitive inhibition, inhibits irreversibly | Enterobacter cloacae | |
benzyl phenylcarbamoyloxycarbamate | o-aryloxycarbonyl hydroxamate, cephalothin as substrate, competitive inhibition, inhibits irreversibly | Enterobacter cloacae | |
biphenyl-4-ylmethyl phenoxycarbonyloxycarbamate | completely inactivated, 2 micro M concentration, o-aryloxycarbonyl hydroxamate, cephalothin as substrate, competitive inhibition, inhibits irreversibly | Enterobacter cloacae | |
clavulanic acid | - |
Enterobacter cloacae | |
N-(phenoxycarbonyloxy)benzenesulfonamide | o-aryloxycarbonyl hydroxamate, cephalothin as substrate, competitive inhibition, inhibits irreversibly | Enterobacter cloacae | |
Sulbactam | - |
Enterobacter cloacae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Enterobacter cloacae | - |
P99 | - |
Enterobacter cloacae P99 | - |
P99 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7R)-7-(benzyloxycarbonylamino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + H2O | - |
Enterobacter cloacae | 2-[(R)-{[(benzyloxy)carbonyl]amino}(carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
(7R)-7-(benzyloxycarbonylamino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + H2O | - |
Enterobacter cloacae P99 | 2-[(R)-{[(benzyloxy)carbonyl]amino}(carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
(7S)-7-(benzyloxycarbonylamino)-3-methyl-8-thioxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + H2O | is 1000000times poorer (kcat and kcat/Km) as a substrate than (7R)-7-(benzyloxycarbonylamino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | Enterobacter cloacae | 2-[(S)-{[(benzyloxy)carbonyl]amino}(carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
(7S)-7-(benzyloxycarbonylamino)-3-methyl-8-thioxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate + H2O | is 1000000times poorer (kcat and kcat/Km) as a substrate than (7R)-7-(benzyloxycarbonylamino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | Enterobacter cloacae P99 | 2-[(S)-{[(benzyloxy)carbonyl]amino}(carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
2-(2-(2-phenylacetamido)acetoxy)acetate + H2O | - |
Enterobacter cloacae | ? | - |
? | |
2-(2-(2-phenylacetamido)acetoxy)acetate + H2O | - |
Enterobacter cloacae P99 | ? | - |
? | |
2-(2-(2-phenylacetamido)ethanethioyloxy)acetate + H2O | 2-(2-(2-phenylacetamido)ethanethioyloxy)acetate is much poorer a substrate than 2-(2-(2-phenylacetamido)acetoxy)acetate | Enterobacter cloacae | ? | - |
? | |
3-(2-(2-phenylacetamido)acetoxy)benzoate + H2O | - |
Enterobacter cloacae | ? | - |
? | |
cephalothin + H2O | - |
Enterobacter cloacae | (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
cephalothin + H2O | - |
Enterobacter cloacae P99 | (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
additional information | 3-(2-(N-methyl-2-phenylacetamido)acetoxy)benzoate is not a substrate | Enterobacter cloacae | ? | - |
? | |
additional information | 3-(2-(N-methyl-2-phenylacetamido)acetoxy)benzoate is not a substrate | Enterobacter cloacae P99 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
class C P99 beta-lactamase | - |
Enterobacter cloacae |
P99 beta-lactamase | - |
Enterobacter cloacae |
serine beta-lactamase | - |
Enterobacter cloacae |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Enterobacter cloacae |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Enterobacter cloacae |