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Literature summary for 3.5.2.6 extracted from

  • Mendonca, N.; Manageiro, V.; Bonnet, R.; Canica, M.
    Biochemical characterization of SHV-55, an extended-spectrum class a beta -lactamase from Klebsiella pneumoniae (2008), Antimicrob. Agents Chemother., 52, 1897-1898.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.2.6

Inhibitors

Inhibitors Comment Organism Structure
clavulanic acid
-
 Klebsiella pneumoniae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
 penicillin G
-
 Klebsiella pneumoniae
0.005
-
 aztreonam
-
 Klebsiella pneumoniae
0.006
-
 ticarcillin
-
 Klebsiella pneumoniae
0.008
-
 piperacillin
-
 Klebsiella pneumoniae
0.009
-
 cephalothin
-
 Klebsiella pneumoniae
0.01
-
 amoxicillin
-
 Klebsiella pneumoniae
0.021
-
 cefotaxime
-
 Klebsiella pneumoniae
0.023
-
 cefuroxime
-
 Klebsiella pneumoniae
0.058
-
 ceftazidime
-
 Klebsiella pneumoniae
0.149
-
 cefepime
-
 Klebsiella pneumoniae

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae Q4TVR4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amoxicillin + H2O
-
 Klebsiella pneumoniae (2R,4S)-2-[(R)-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
aztreonam + H2O
-
 Klebsiella pneumoniae [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate
-
 ?
cefepime + H2O
-
 Klebsiella pneumoniae (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
cefotaxime + H2O
-
 Klebsiella pneumoniae (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
ceftazidime + H2O
-
 Klebsiella pneumoniae (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
cefuroxime + H2O
-
 Klebsiella pneumoniae (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
cephalothin + H2O
-
 Klebsiella pneumoniae (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
penicillin G + H2O
-
 Klebsiella pneumoniae (2R,4S)-2-[(R)-carboxy[(phenylacetyl)amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
piperacillin + H2O
-
 Klebsiella pneumoniae (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
ticarcillin + H2O
-
 Klebsiella pneumoniae (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Synonyms

Synonyms Comment Organism
beta-lactamase
-
 Klebsiella pneumoniae
SHV-55
-
 Klebsiella pneumoniae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.1
-
 aztreonam above Klebsiella pneumoniae
7
-
 cefuroxime
-
 Klebsiella pneumoniae
8
-
 ticarcillin
-
 Klebsiella pneumoniae
9
-
 ceftazidime
-
 Klebsiella pneumoniae
23
-
 penicillin G
-
 Klebsiella pneumoniae
23
-
 amoxicillin
-
 Klebsiella pneumoniae
24
-
 cefotaxime
-
 Klebsiella pneumoniae
27
-
 piperacillin
-
 Klebsiella pneumoniae
30
-
 cefepime
-
 Klebsiella pneumoniae
38
-
 cephalothin
-
 Klebsiella pneumoniae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00002
-
-
 Klebsiella pneumoniae clavulanic acid