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Literature summary for 3.5.2.6 extracted from

  • Takeda, S.; Nakai, T.; Ikeda, F.; Hatano, K.
    Overproduction of a metallo-beta-lactamase by a strong promoter causes high-level imipenem resistance in a clinical isolate of Pseudomonas aeruginosa (2008), Chemotherapy, 54, 181-187.
    View publication on PubMed
Search for more literature for 3.5.2.6

Cloned(Commentary)

Cloned (Comment) Organism
gene blaIMP-10, DNA and amino acid sequence determination and analysis, promoter analysis, overexpression of metallo-beta-lactamase IMP-10 by the strong promoter of gene blaIMP-10 in Pseudomonas aeruginosa strain KG2505, overview. Genetic structure of the class 1 integron carrying the blaIMP-10 cassette, overview Pseudomonas aeruginosa

Protein Variants

Protein Variants Comment Organism
additional information overproduction of a metallo-beta-lactamase by a strong promoter causes high-level imipenem resistance in a strain KG2505, PAO1 derivative without an AmpC beta-lactamase and a Mex-AB-OprM efflux pump, derived from a clinical human isolate of Pseudomonas aeruginosa, overview Pseudomonas aeruginosa

Metals/Ions

Metals/Ions Comment Organism Structure
additional information metallo-beta-lactamase Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
imipenem + H2O Pseudomonas aeruginosa
-
 (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
additional information Pseudomonas aeruginosa susceptibility and enzymatic activity of metallo-beta-lactamases in Pseudomonas aeruginosa-producing metallo-beta-lactamases, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q7DH52 IMP-10; gene blaIMP-10
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
imipenem + H2O
-
 Pseudomonas aeruginosa (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
imipenem + H2O high activity of IMP-10 Pseudomonas aeruginosa (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
additional information susceptibility and enzymatic activity of metallo-beta-lactamases in Pseudomonas aeruginosa-producing metallo-beta-lactamases, overview Pseudomonas aeruginosa ?
-
 ?

Synonyms

Synonyms Comment Organism
IMP-10
-
 Pseudomonas aeruginosa
metallo-beta-lactamase
-
 Pseudomonas aeruginosa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Pseudomonas aeruginosa