Literature summary for 3.5.2.6 extracted from

Yamaguchi, Y.; Jin, W.; Matsunaga, K.; Ikemizu, S.; Yamagata, Y.; Wachino, J.; Shibata, N.; Arakawa, Y.; Kurosaki, H.
Crystallographic investigation of the inhibition mode of a VIM-2 metallo-beta-lactamase from Pseudomonas aeruginosa by a mercaptocarboxylate inhibitor (2007), J. Med. Chem., 50, 6647-6653.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli NCB326-1B2 cells	Pseudomonas aeruginosa

Crystallization (Commentary)

Crystallization (Comment)	Organism
in complex with rac-2-omega-phenylpropyl-3-mercaptopropionic acid, in 30% PEG MME5000, 0.1 M MES-NaOH, and 0.2 M ammonium sulfate (pH 6.5)	Pseudomonas aeruginosa

Inhibitors

Inhibitors	Comment	Organism	Structure
rac-2-omega-phenylpropyl-3-mercaptopropionic acid	potent inhibitor	Pseudomonas aeruginosa

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	two Zn2+ ions are located at the active sites	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Pseudomonas aeruginosa

Synonyms

Synonyms	Comment	Organism
VIM-2 metallo-beta-lactamase	-	Pseudomonas aeruginosa

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00022	-	rac-2-omega-phenylpropyl-3-mercaptopropionic acid	-	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)