Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | imipenem and cefoxitin do not induce OXA-114 expression | Achromobacter xylosoxidans |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli Top10 cells | Achromobacter xylosoxidans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
clavulanate | - |
Achromobacter xylosoxidans | |
Sulbactam | - |
Achromobacter xylosoxidans | |
tazobactam | - |
Achromobacter xylosoxidans |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
piperacillin | in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C | Achromobacter xylosoxidans | |
0.01 | - |
benzylpenicillin | in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C | Achromobacter xylosoxidans | |
0.015 | - |
cephalothin | in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C | Achromobacter xylosoxidans | |
0.04 | - |
ticarcillin | in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C | Achromobacter xylosoxidans | |
2 | - |
Imipenem | Km above 2 mM, in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C | Achromobacter xylosoxidans |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
27000 | - |
SDS-PAGE | Achromobacter xylosoxidans |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Achromobacter xylosoxidans | B3FIE3 | strain CIP69598, previously Alcaligenes xylosoxidans | - |
Purification (Comment) | Organism |
---|---|
Q-Sepharose column chromatography and S-Sepharose column chromatography | Achromobacter xylosoxidans |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzylpenicillin + H2O | - |
Achromobacter xylosoxidans | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
cephalothin + H2O | - |
Achromobacter xylosoxidans | (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
imipenem + H2O | - |
Achromobacter xylosoxidans | (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid | - |
? | |
additional information | no hydrolysis of oxacillin, ceftazidime, cefotaxime, and cefoxitin | Achromobacter xylosoxidans | ? | - |
? | |
piperacillin + H2O | - |
Achromobacter xylosoxidans | (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
ticarcillin + H2O | - |
Achromobacter xylosoxidans | (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
OXA114 | a class D beta-lactamase | Achromobacter xylosoxidans |
Oxacillinase | - |
Achromobacter xylosoxidans |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1 | - |
benzylpenicillin | in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C | Achromobacter xylosoxidans | |
0.1 | - |
ticarcillin | in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C | Achromobacter xylosoxidans | |
0.5 | - |
cephalothin | in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C | Achromobacter xylosoxidans | |
0.5 | - |
piperacillin | in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C | Achromobacter xylosoxidans |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Achromobacter xylosoxidans | isoelectric focusing | - |
8.6 |