Cloned (Comment) | Organism |
---|---|
- |
Laribacter hongkongensis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
clavulanate | IC50: 0.138 mM | Laribacter hongkongensis | |
Cloxacillin | IC50: 0.0035 mM | Laribacter hongkongensis | |
Sulbactam | IC50: 0.057 mM | Laribacter hongkongensis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.056 | - |
cephalothin | - |
Laribacter hongkongensis | |
0.088 | - |
cephaloridine | - |
Laribacter hongkongensis | |
0.356 | - |
benzylpenicillin | - |
Laribacter hongkongensis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Laribacter hongkongensis | expression of the ampC gene of HLHK5 is regulated by its ampR gene, which acts as a repressor | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Laribacter hongkongensis | Q6GVZ4 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzylpenicillin + H2O | 2.8% of the activity with cephaloridine | Laribacter hongkongensis | (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid | - |
? | |
cefepime + H2O | 1.05% of the activity with cephaloridine | Laribacter hongkongensis | (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
cephaloridine + H2O | - |
Laribacter hongkongensis | (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate | - |
? | |
cephalothin + H2O | 101% of the activity with cephaloridine | Laribacter hongkongensis | (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid | - |
? | |
additional information | expression of the ampC gene of HLHK5 is regulated by its ampR gene, which acts as a repressor | Laribacter hongkongensis | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AmpC beta-lactamase | - |
Laribacter hongkongensis |
LHK-5 | - |
Laribacter hongkongensis |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Laribacter hongkongensis | isolelectric focusing, pH-range 3.5-9.5 | - |
8.1 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0035 | - |
IC50: 0.0035 mM | Laribacter hongkongensis | Cloxacillin | |
0.057 | - |
IC50: 0.057 mM | Laribacter hongkongensis | Sulbactam | |
0.138 | - |
IC50: 0.138 mM | Laribacter hongkongensis | clavulanate |