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Literature summary for 3.5.2.6 extracted from

  • Lau, S.K.; Ho, P.L.; Li, M.W.; Tsoi, H.W.; Yung, R.W.; Woo, P.C.; Yuen, K.Y.
    Cloning and characterization of a chromosomal class C beta-lactamase and its regulatory gene in Laribacter hongkongensis (2005), Antimicrob. Agents Chemother., 49, 1957-1964.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Laribacter hongkongensis

Inhibitors

Inhibitors Comment Organism Structure
clavulanate IC50: 0.138 mM Laribacter hongkongensis
Cloxacillin IC50: 0.0035 mM Laribacter hongkongensis
Sulbactam IC50: 0.057 mM Laribacter hongkongensis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.056
-
cephalothin
-
Laribacter hongkongensis
0.088
-
cephaloridine
-
Laribacter hongkongensis
0.356
-
benzylpenicillin
-
Laribacter hongkongensis

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Laribacter hongkongensis expression of the ampC gene of HLHK5 is regulated by its ampR gene, which acts as a repressor ?
-
?

Organism

Organism UniProt Comment Textmining
Laribacter hongkongensis Q6GVZ4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzylpenicillin + H2O 2.8% of the activity with cephaloridine Laribacter hongkongensis (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
cefepime + H2O 1.05% of the activity with cephaloridine Laribacter hongkongensis (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cephaloridine + H2O
-
Laribacter hongkongensis (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cephalothin + H2O 101% of the activity with cephaloridine Laribacter hongkongensis (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
additional information expression of the ampC gene of HLHK5 is regulated by its ampR gene, which acts as a repressor Laribacter hongkongensis ?
-
?

Synonyms

Synonyms Comment Organism
AmpC beta-lactamase
-
Laribacter hongkongensis
LHK-5
-
Laribacter hongkongensis

pI Value

Organism Comment pI Value Maximum pI Value
Laribacter hongkongensis isolelectric focusing, pH-range 3.5-9.5
-
8.1

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0035
-
IC50: 0.0035 mM Laribacter hongkongensis Cloxacillin
0.057
-
IC50: 0.057 mM Laribacter hongkongensis Sulbactam
0.138
-
IC50: 0.138 mM Laribacter hongkongensis clavulanate