Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,6-dipicolinic acid | - |
Bos taurus | |
2,6-dipicolinic acid | - |
Rattus norvegicus | |
8-Hydroxyquinoline-5-sulfonic acid | - |
Bos taurus | |
8-Hydroxyquinoline-5-sulfonic acid | - |
Rattus norvegicus | |
N-Carbamoyl-beta-alanine | product inhibition | Rattus norvegicus | |
N-carbamoyl-beta-aminoisobutyric acid | product inhibition | Rattus norvegicus | |
Zn2+ | irreversible inhibition | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
5,6-Dihydrothymine | pH 8.2 | Rattus norvegicus | |
0.017 | - |
5-bromo-5,6-dihydrouracil | pH 8.2 | Rattus norvegicus | |
0.019 | - |
5,6-dihydrouracil | pH 7.0 | Rattus norvegicus | |
0.02 | - |
5,6-dihydrouracil | pH 8.2 | Rattus norvegicus | |
0.025 | - |
5-bromo-5,6-dihydrouracil | pH 7.0 | Rattus norvegicus | |
0.026 | - |
5,6-Dihydrothymine | pH 7.0 | Rattus norvegicus | |
1.19 | - |
N-carbamoyl-beta-aminoisobutyric acid | pH 7.0 | Rattus norvegicus | |
1.59 | - |
N-carbamoyl-beta-aminoisobutyric acid | pH 8.2 | Rattus norvegicus | |
1.92 | - |
N-Carbamoyl-beta-alanine | pH 7.0 | Rattus norvegicus | |
2.26 | - |
N-Carbamoyl-beta-alanine | pH 8.2 | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
cytosol | - |
Bos taurus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | essential, metalloenzyme | Rattus norvegicus | |
Zn2+ | essential, metalloenzyme | Bos taurus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
54000 | - |
4 * 54000, SDS-PAGE | Rattus norvegicus |
215000 | - |
gel filtration | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,6-dihydropyrimidine + H2O | Rattus norvegicus | - |
beta-ureido acid | - |
r | |
5,6-dihydropyrimidine + H2O | Bos taurus | - |
beta-ureido acid | - |
r | |
5,6-dihydrothymine + H2O | Rattus norvegicus | - |
? | - |
r | |
5,6-dihydrothymine + H2O | Bos taurus | - |
? | - |
r | |
5,6-dihydrouracil + H2O | Bos taurus | - |
3-ureidopropionate | - |
r | |
hydantoin + H2O | Homo sapiens | - |
N-carbamoyl glycine | - |
? | |
hydantoin + H2O | Rattus norvegicus | - |
N-carbamoyl glycine | - |
r | |
hydantoin + H2O | Bos taurus | - |
N-carbamoyl glycine | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
calf | - |
Bos taurus | - |
bovine | - |
Homo sapiens | - |
human | - |
Rattus norvegicus | - |
rat | - |
Purification (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
ascites | - |
Rattus norvegicus | - |
brain | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
kidney | - |
Bos taurus | - |
liver | - |
Rattus norvegicus | - |
liver | - |
Bos taurus | - |
lung | - |
Rattus norvegicus | - |
small intestine | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
14.8 | - |
- |
Rattus norvegicus |
Storage Stability | Organism |
---|---|
4°C, purified enzyme, 20% decrease in specific activity observed within 2 months | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-methylhydantoin + H2O | poor substrate | Rattus norvegicus | 3-methylhydantoic acid | - |
? | |
5,6-dihydropyrimidine + H2O | - |
Rattus norvegicus | beta-ureido acid | - |
r | |
5,6-dihydropyrimidine + H2O | - |
Bos taurus | beta-ureido acid | - |
r | |
5,6-dihydrothymine + H2O | - |
Rattus norvegicus | ? | - |
r | |
5,6-dihydrothymine + H2O | - |
Bos taurus | ? | - |
r | |
5,6-dihydrouracil + H2O | - |
Rattus norvegicus | 3-ureidopropionate | - |
r | |
5,6-dihydrouracil + H2O | - |
Bos taurus | 3-ureidopropionate | - |
r | |
5-bromo-5,6-dihydrouracil + H2O | - |
Rattus norvegicus | ? | - |
? | |
5-bromo-5,6-dihydrouracil + H2O | - |
Bos taurus | ? | - |
? | |
5-fluoro-5,6-dihydrouracil + H2O | - |
Rattus norvegicus | ? | - |
? | |
carbamoyl beta-aminoisobutyric acid + H2O | - |
Rattus norvegicus | ? | - |
? | |
carbamoyl beta-aminoisobutyric acid + H2O | - |
Bos taurus | ? | - |
? | |
D-5-methylhydantoin + H2O | - |
Bos taurus | N-carbamoyl-D-alanine | - |
? | |
D-5-methylhydantoin + H2O | L-5-methylhydantoin is no substrate | Rattus norvegicus | N-carbamoyl-D-alanine | - |
? | |
dihydropyrimidine + H2O | - |
Rattus norvegicus | N-carbamoyl amino acid | - |
r | |
dihydropyrimidine + H2O | - |
Bos taurus | N-carbamoyl amino acid | - |
r | |
DL-5-isopropylhydantoin + H2O | only D-isomer hydrolyzed | Rattus norvegicus | N-carbamoyl-D-valine | - |
? | |
glutarimide + H2O | - |
Rattus norvegicus | ? | - |
? | |
glutarimide + H2O | - |
Bos taurus | ? | - |
? | |
hydantoin + H2O | - |
Homo sapiens | N-carbamoyl glycine | - |
? | |
hydantoin + H2O | - |
Rattus norvegicus | N-carbamoyl glycine | - |
r | |
hydantoin + H2O | - |
Bos taurus | N-carbamoyl glycine | - |
r | |
additional information | - |
Bos taurus | ? | - |
? | |
additional information | succinimide, dihydro-L-orotic-2-acid, dihydrouridine and dihydrothymidine are no substrates | Rattus norvegicus | ? | - |
? | |
N-carbamoyl beta-alanine + H2O | - |
Rattus norvegicus | 5,6-dihydrouracil | - |
r | |
N-carbamoyl beta-alanine + H2O | - |
Bos taurus | 5,6-dihydrouracil | - |
r |
Subunits | Comment | Organism |
---|---|---|
tetramer | - |
Bos taurus |
tetramer | 4 * 54000, SDS-PAGE | Rattus norvegicus |