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Literature summary for 3.5.1.98 extracted from

  • Munkhjargal, T.; Aboulaila, M.; Ueno, A.; Sivakumar, T.; Nakano, Y.; Yokoyama, M.; Yokoyama, N.; Igarashi, I.
    Cloning and characterization of histone deacetylase from Babesia bovis (2012), Vet. Parasitol., 190, 423-433.
    View publication on PubMed
Search for more literature for 3.5.1.98

Application

Application Comment Organism
drug development the enzyme might be a promising target for the development of novel anti-babesial drugs Babesia bovis

Cloned(Commentary)

Cloned (Comment) Organism
DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of GST-tagged isozyme HDAC3 in Escherichia coli Babesia bovis

Inhibitors

Inhibitors Comment Organism Structure
cyclo (N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl) i.e. apicidin, a cyclic tetrapeptide having broad-spectrum antiparasitic activity, inhibits the enzyme activity as well as the in vitro growth of Babesia parasites with an IC50 of 3.8 ng/ml Babesia bovis

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ required, enzyme bound Babesia bovis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51200
-
 x * 51200, isozyme HDAC3, SDS-PAGE, x * 77200, recombinant GST-tagged isozyme HDAC3, SDS-PAGE Babesia bovis
77200
-
 x * 51200, isozyme HDAC3, SDS-PAGE, x * 77200, recombinant GST-tagged isozyme HDAC3, SDS-PAGE Babesia bovis

Organism

Organism UniProt Comment Textmining
Babesia bovis
-
 isozyme HDAC3
-

Subunits

Subunits Comment Organism
? x * 51200, isozyme HDAC3, SDS-PAGE, x * 77200, recombinant GST-tagged isozyme HDAC3, SDS-PAGE Babesia bovis

Synonyms

Synonyms Comment Organism
HDAC
-
 Babesia bovis
HDAC 3
-
 Babesia bovis
HDAC3
-
 Babesia bovis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Babesia bovis