Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MS-275 | inhibition of HDAC1 leads to a significant increase of global acetylation of residues K9 and K14 on histone H3, which is a feature of active transcription, and a significant induction of proinflammatory cytokine expression. Genomic DNA corresponding to the IL1beta and IL6 promoter is significantly enriched upon HDAC 1 inhibition | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
MDA-MB-231 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
HDAC1 | - |
Homo sapiens |
histone deacetylase 1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Lysine-specific demethylase 1 has a repressive role in proinflammatory cytokine expression such as IL1alpha, IL1b,eta IL6 and IL8 and classical complement components. HDAC1 and lysine-specific demethylase 1 synergistically regulate these inflammatory-related genes | Homo sapiens |