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Literature summary for 3.5.1.98 extracted from

  • Janzer, A.; Lim, S.; Fronhoffs, F.; Niazy, N.; Buettner, R.; Kirfel, J.
    Lysine-specific demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) synergistically repress proinflammatory cytokines and classical complement pathway components (2012), Biochem. Biophys. Res. Commun., 421, 665-670.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
MS-275 inhibition of HDAC1 leads to a significant increase of global acetylation of residues K9 and K14 on histone H3, which is a feature of active transcription, and a significant induction of proinflammatory cytokine expression. Genomic DNA corresponding to the IL1beta and IL6 promoter is significantly enriched upon HDAC 1 inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
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MDA-MB-231 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
HDAC1
-
 Homo sapiens
histone deacetylase 1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function Lysine-specific demethylase 1 has a repressive role in proinflammatory cytokine expression such as IL1alpha, IL1b,eta IL6 and IL8 and classical complement components. HDAC1 and lysine-specific demethylase 1 synergistically regulate these inflammatory-related genes Homo sapiens