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Literature summary for 3.5.1.98 extracted from
- Inhibition of histone deacetylase 10 induces thioredoxin-interacting protein and causes accumulation of reactive oxygen species in SNU-620 human gastric cancer cells (2010), Mol. Cells, 30, 107-112.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| LAQ824 | pan-HDAC inhibitor | Homo sapiens |  |
| additional information | HDAC10 is not inhibited by SK7068, MS275, and oxamflatin | Homo sapiens | |
| sodium butyrate | pan-HDAC inhibitor | Homo sapiens | |
| suberoylanilide hydroxamic acid | pan-HDAC inhibitor | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Homo sapiens | 5737 | - |
| nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-tubulin + H2O | Homo sapiens | - |
acetate + ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| gastric cancer cell | - |
Homo sapiens | - |
| SNU-620 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alpha-tubulin + H2O | - |
Homo sapiens | acetate + ? | - |
? | |
| N6-lysine acetylated histone H3 + H2O | - |
Homo sapiens | histone H3 + acetate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HDAC10 | - |
Homo sapiens |
| histone deacetylase 10 | a class IIb histone deacetylase | Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | knockdown of HDAC10 significantly increases the mRNA expression levels of thioredoxin-interacting protein and induces release of cytochrome c and activated apoptotic signaling molecules through accumulation of reactive oxygen species in SNU-620 human gastric cancer cells | Homo sapiens |
| physiological function | HDAC10 is involved in transcriptional downregulation of thioredoxin-interacting protein, leading to altered reactive oxygen species signaling in human gastric cancer cells | Homo sapiens |
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