Literature summary for 3.5.1.98 extracted from

Lee, K.H.; Choi, E.Y.; Kim, M.K.; Kim, K.O.; Jang, B.I.; Kim, S.W.; Kim, S.W.; Song, S.K.; Kim, J.R.
Inhibition of histone deacetylase activity down-regulates urokinase plasminogen activator and matrix metalloproteinase-9 expression in gastric cancer (2010), Mol. Cell. Biochem., 343, 163-171.

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Inhibitors

Inhibitors	Comment	Organism	Structure
trichostatin A	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
MKN-28 cell	-	Homo sapiens	-
NUGC-3 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
HDAC5	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	hepatocyte growth factor induces HDAC-5 expression in gastric cancer cells. GO6976, a PKC inhibitor, significantly inhibits hepatocyte growth factor-induced HDAC5 expression	up

General Information

General Information	Comment	Organism
malfunction	inhibition of histone deacetylase activity down-regulates urokinase plasminogen activator and matrix metalloproteinase-9 expression in gastric cancer	Homo sapiens
physiological function	HDACs regulate hepatocyte growth factor-induced urokinase plasminogen activator and matrix metalloproteinase-9 expression through a protein kinase C-dependent signal pathway in gastric cancer cells	Homo sapiens

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Release 2023.1 (January 2023)