Protein Variants | Comment | Organism |
---|---|---|
K432R | the HDAC1 mutant only partially loses acetylation modification | Homo sapiens |
R433K | the HDAC2 mutant is only acetylated at low levels | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetylated histone deacetylase 1 | the activity of HDAC2 is inhibited by acetylated HDAC1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
acetylation | HDAC, but not HDAC2 is acetylated by p300 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-lysine-histone H3 + H2O | - |
Homo sapiens | acetate + histone H3 | - |
? | |
N-acetyl-lysine-histone H4 + H2O | - |
Homo sapiens | acetate + histone H4 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDAC1 | - |
Homo sapiens |
HDAC2 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | HDAC2 and HDAC1 are required for glucocorticoid receptor-mediated gene activation. HDAC2, however, is regulated through a different mechanism from that of HDAC1. Acetylated HDAC1 can trans-regulate HDAC2 through heterodimerization. Both HDAC1 and HDAC2 are required for mouse mammary tumor virus transcription | Homo sapiens |