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Literature summary for 3.5.1.98 extracted from

  • Hong, S.; Derfoul, A.; Pereira-Mouries, L.; Hall, D.J.
    A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes (2009), FASEB J., 23, 3539-3552.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
trichostatin A
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
chondrocyte
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
HDAC1
-
Homo sapiens
HDAC2
-
Homo sapiens
histone deacetylase 1
-
Homo sapiens
histone deacetylase 2
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens HDAC1 and HDAC2 protein levels are elevated in chondrocytes from osteoarthritic patients up

General Information

General Information Comment Organism
malfunction HDAC1 and HDAC2 with carboxy-terminal domains deleted, retain enzymatic activity but are unable to repress cartilage gene expression Homo sapiens
physiological function HDAC1 and HDAC2 repress aggrecan and collagen 2(alpha1) expression but differ in their repression of collagen 9(alpha1), collagen 11(alpha1), dermatopontin, and cartilage oligomeric matrix protein. Carboxy-terminal domains of HDAC1 and HDAC2 are not required for enzymatic activity in vitro but are required for optimal deacetylation in vivo and repression of cartilage-specific gene expression Homo sapiens