Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-dihydrobenzoic acid | 98% residual activity at 0.5 mM | Homo sapiens | |
2-hydroxybutyric acid | 96% residual activity at 0.5 mM | Homo sapiens | |
3,4-Dihydroxyphenyl acetic acid | 90% residual activity at 0.5 mM | Homo sapiens | |
3-hydroxycinnamic acid | 96% residual activity at 0.5 mM | Homo sapiens | |
8-hydroxyquinoline | 85% residual activity at 0.5 mM | Homo sapiens | |
Baclofen | 98% residual activity at 0.5 mM | Homo sapiens | |
Butyric acid | - |
Homo sapiens | |
caffeic acid | 80% residual activity at 0.5 mM | Homo sapiens | |
chlorogenic acid | highly potent HDAC inhibitor, 40% residual activity at 0.5 mM | Homo sapiens | |
Cinnamic acid | 95% residual activity at 0.5 mM | Homo sapiens | |
curcumin | highly potent HDAC inhibitor, 52% residual activity at 0.5 mM | Homo sapiens | |
D-(-)-quinic acid | 96% residual activity at 0.5 mM | Homo sapiens | |
dihydrocaffeic acid | 86% residual activity at 0.5 mM | Homo sapiens | |
ferulic acid | 80% residual activity at 0.5 mM | Homo sapiens | |
gamma-aminobutyric acid | - |
Homo sapiens | |
indol-2-carboxylic acid | 97% residual activity at 0.5 mM | Homo sapiens | |
isobutyric acid | 80% residual activity at 0.5 mM | Homo sapiens | |
Mandelic acid | 85% residual activity at 0.5 mM | Homo sapiens | |
additional information | HDAC is not inhibited by isovaleric acid, L-valine, sodium lactate, succinic acid, citric acid, benzylic acid, hippuric acid, antranilic acid (2-aminobenzoic acid), alpha-hydroxyacetonaphthone, and kojic acid | Homo sapiens | |
phenyl butyric acid | - |
Homo sapiens | |
phenylbutyric acid | - |
Homo sapiens | |
propionic acid | 80% residual activity at 0.5 mM | Homo sapiens | |
salicylic acid | 92% residual activity at 0.5 mM | Homo sapiens | |
sodium butyrate | - |
Homo sapiens | |
sodium phenylbutyrate | - |
Homo sapiens | |
sorbic acid | 91% residual activity at 0.5 mM | Homo sapiens | |
suberoyl anilide hydroxamic acid | - |
Homo sapiens | |
tartaric acid | 90% residual activity at 0.5 mM | Homo sapiens | |
trichostatin A | - |
Homo sapiens | |
Valeric acid | 83% residual activity at 0.5 mM | Homo sapiens | |
Valproic acid | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BY41 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
tert-butyloxycarbonyl-L-Lys(acetyl)-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | tert-butyloxycarbonyl-L-Lys-7-amido-4-methylcoumarin + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDAC8 | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00000821 | - |
Cinnamic acid | pH and temperature not specified in the publication | Homo sapiens | |
0.000135 | - |
chlorogenic acid | pH and temperature not specified in the publication | Homo sapiens | |
0.000504 | - |
trichostatin A | pH and temperature not specified in the publication | Homo sapiens | |
0.000539 | - |
curcumin | pH and temperature not specified in the publication | Homo sapiens | |
0.00247 | - |
suberoyl anilide hydroxamic acid | pH and temperature not specified in the publication | Homo sapiens | |
0.0028 | - |
phenyl butyric acid | pH and temperature not specified in the publication | Homo sapiens | |
0.00634 | - |
sodium phenylbutyrate | pH and temperature not specified in the publication | Homo sapiens | |
0.00819 | - |
gamma-aminobutyric acid | pH and temperature not specified in the publication | Homo sapiens | |
0.01084 | - |
caffeic acid | pH and temperature not specified in the publication | Homo sapiens | |
0.136 | - |
Butyric acid | pH and temperature not specified in the publication | Homo sapiens | |
0.365 | - |
sodium butyrate | pH and temperature not specified in the publication | Homo sapiens | |
0.564 | - |
Valproic acid | pH and temperature not specified in the publication | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.115 | - |
pH and temperature not specified in the publication | Homo sapiens | curcumin | |
0.375 | - |
pH and temperature not specified in the publication | Homo sapiens | chlorogenic acid | |
2.54 | - |
pH and temperature not specified in the publication | Homo sapiens | caffeic acid |