Literature summary for 3.5.1.98 extracted from

Chetan, B.; Bunha, M.; Jagrat, M.; Sinha, B.N.; Saiko, P.; Graser, G.; Szekeres, T.; Raman, G.; Rajendran, P.; Moorthy, D.; Basu, A.; Jayaprakash, V.
Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity (2010), Bioorg. Med. Chem. Lett., 20, 3906-3910.

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Inhibitors

Inhibitors	Comment	Organism	Structure
(2E)-3-[4-([[2-(3a,7a-dihydro-1H-indol-3-yl)ethyl](2-hydroxyethyl)amino]methyl)phenyl]-N-hydroxyprop-2-enamide	-	Homo sapiens
4-[[(2E)-2-(2-chlorobenzylidene)hydrazinyl]carbonothioyl]-N-hydroxypiperazine-1-carboxamide	-	Homo sapiens
4-[[(2E)-2-(4-chlorobenzylidene)hydrazinyl]carbonothioyl]-N-hydroxypiperazine-1-carboxamide	inactivates HDAC8 preferentially over HDAC1	Homo sapiens
4-[[(2E)-2-(anthracen-9-ylmethylidene)hydrazinyl]carbonothioyl]-N-hydroxypiperazine-1-carboxamide	-	Homo sapiens
MS-275	-	Homo sapiens
N-hydroxy-4-[[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]carbonothioyl]piperazine-1-carboxamide	inactivates HDAC8 preferentially over HDAC1	Homo sapiens
N-hydroxy-4-[[(2E)-2-(4-methylbenzylidene)hydrazinyl]carbonothioyl]piperazine-1-carboxamide	-	Homo sapiens
N-hydroxy-4-[[(2Z)-2-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)hydrazinyl]carbonothioyl]piperazine-1-carboxamide	-	Homo sapiens
NVP-LAQ824	-	Homo sapiens
suberoyl anilide hydroxamic acid	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9BY41	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HCT-116 cell	-	Homo sapiens	-
NCI-H460 cell	-	Homo sapiens	-
U-251 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
HDAC8	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000045	-	pH and temperature not specified in the publication	Homo sapiens	(2E)-3-[4-([[2-(3a,7a-dihydro-1H-indol-3-yl)ethyl](2-hydroxyethyl)amino]methyl)phenyl]-N-hydroxyprop-2-enamide
0.03367	-	pH and temperature not specified in the publication	Homo sapiens	N-hydroxy-4-[[(2E)-2-(2-hydroxybenzylidene)hydrazinyl]carbonothioyl]piperazine-1-carboxamide
0.04316	-	pH and temperature not specified in the publication	Homo sapiens	4-[[(2E)-2-(4-chlorobenzylidene)hydrazinyl]carbonothioyl]-N-hydroxypiperazine-1-carboxamide

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Release 2023.1 (January 2023)