Application | Comment | Organism |
---|---|---|
medicine | type I ribosome-inactivating proteins derived from plants are HDAC inhibitors that can be utilized in the prevention and treatment of prostate cancer | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
MCP30 | 30 kDa protein isolated from bitter melon seeds, Momordica charantia, contains two highly related type I ribosome-inactivating proteins, alpha- and beta-momorcharin | Homo sapiens | |
trichostatin A | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | histone deacetylases catalyze the removal of acetyl groups from histones, leading to chromatin condensation and transcriptional repression | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q13547 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LNCaP cell | - |
Homo sapiens | - |
PC-3 cell | - |
Homo sapiens | - |
prostate cancer cell line | - |
Homo sapiens | - |
prostate gland intraepithelial neoplasia cell line | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | histone deacetylases catalyze the removal of acetyl groups from histones, leading to chromatin condensation and transcriptional repression | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
histone deacetylase-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
activity assay | Homo sapiens |