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Literature summary for 3.5.1.98 extracted from

  • Nian, H.; Delage, B.; Ho, E.; Dashwood, R.H.
    Modulation of histone deacetylase activity by dietary isothiocyanates and allyl sulfides: studies with sulforaphane and garlic organosulfur compounds (2009), Environ. Mol. Mutagen., 50, 213-221.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine HDAC inhibitors in food may help reverse aberrant patterns of histone changes in cancer cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
allyl mercaptan garlic organosulfur compounds can be metabolized to allyl mercaptan Homo sapiens
Butyrate
-
 Homo sapiens
Isothiocyanate found in cruciferous vegetables Homo sapiens
phenylbutyrate Buphenyl Homo sapiens
suberoylanilide hydroxamic acid SAHA Homo sapiens
sulforaphane SFN, found in broccoli sprouts Homo sapiens
trichostatin A TSA Homo sapiens
Valproic acid Depakene, Convulex Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9BY41
-
-

Source Tissue

Source Tissue Comment Organism Textmining
BPH-1 cell
-
 Homo sapiens
-
breast cancer cell line
-
 Homo sapiens
-
colonic cancer cell line
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
LNCaP cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
HDAC
-
 Homo sapiens
histone deacetylase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.024
-
 allyl mercaptan human HDAC8 Homo sapiens
0.046
-
 Butyrate
-
 Homo sapiens