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Literature summary for 3.5.1.98 extracted from

  • Balasubramanian, S.; Verner, E.; Buggy, J.J.
    Isoform-specific histone deacetylase inhibitors: The next step? (2009), Cancer Lett., 280, 211-221.
    View publication on PubMed

Application

Application Comment Organism
medicine HDAC inhibitors have attracted a great deal of interest as drug targets in recent years Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2E)-N-hydroxy-3-naphthalen-1-ylprop-2-enamide HDAC8-selective inhibitor Homo sapiens
2,2,2-trifluoro-1-[5-(3-methyl-1,2,4-oxadiazol-5-yl)thiophen-2-yl]ethanone HDAC4-selective inhibitor Homo sapiens
Butyrate class I-selective HDAC inhibitor Homo sapiens
ITF-2357 broad-spectrum or pan-HDAC inhibitor Homo sapiens
JNJ-26481585 broad-spectrum or pan-HDAC inhibitor Homo sapiens
LBH-589 panobinostat, broad-spectrum or pan-HDAC inhibitor Homo sapiens
MGCD-0103 mocetinostat dihydrobromide, class I-selective HDAC inhibitor Homo sapiens
MS-275 SNDX-275, entinostat, class I-selective HDAC inhibitor Homo sapiens
N-hydroxy-1-methyl-indole-6-carboxamide HDAC8-selective inhibitor Homo sapiens
N-hydroxynaphthalene-1-carboxamide HDAC8-selective inhibitor Homo sapiens
PCI-24781 broad-spectrum or pan-HDAC inhibitor Homo sapiens
PCI-34051 HDAC8-selective inhibitor Homo sapiens
PXD-101 belinostat, broad-spectrum or pan-HDAC inhibitor Homo sapiens
romidepsin FK-228, FR901228, depsipeptide, class I-selective HDAC inhibitor Homo sapiens
suberoylanilide hydroxamic acid SAHA, vorinostat, zolinza, broad-spectrum or pan-HDAC inhibitor Homo sapiens
tubacin HDAC6-selective inhibitor Homo sapiens
Valproate class I-selective HDAC inhibitor Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
HDAC
-
Homo sapiens
histone deacetylase
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000015
-
PCI-34051 HDAC8 inhibition Homo sapiens
0.0007
-
(2E)-N-hydroxy-3-naphthalen-1-ylprop-2-enamide HDAC8 inhibition Homo sapiens
0.0013
-
N-hydroxy-1-methyl-indole-6-carboxamide HDAC8 inhibition Homo sapiens
0.0085
-
N-hydroxy-1-methyl-indole-6-carboxamide HDAC1 inhibition Homo sapiens
0.014
-
N-hydroxynaphthalene-1-carboxamide HDAC8 inhibition Homo sapiens