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Literature summary for 3.5.1.98 extracted from

  • Chen, P.C.; Patil, V.; Guerrant, W.; Green, P.; Oyelere, A.K.
    Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group (2008), Bioorg. Med. Chem., 16, 4839-4853.
    View publication on PubMed

Application

Application Comment Organism
medicine HDAC inhibition is a clinically validated therapeutic strategy for cancer treatment Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-(4-benzyl-1H-1,2,3-triazol-1-yl)-N-hydroxypentanamide
-
Homo sapiens
6-[4-(2,6-dimethoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxyhexanamide
-
Homo sapiens
6-[4-(biphenyl-2-yl)-1H-1,2,3-triazol-1-yl]-N-hydroxyhexanamide
-
Homo sapiens
6-[4-(biphenyl-3-yl)-1H-1,2,3-triazol-1-yl]-N-hydroxyhexanamide
-
Homo sapiens
6-[4-(biphenyl-4-yl)-1H-1,2,3-triazol-1-yl]-N-hydroxyhexanamide
-
Homo sapiens
6-{4-[4-(dimethylamino)phenyl]-1H-1,2,3-triazol-1-yl}-N-hydroxyhexanamide
-
Homo sapiens
7-[4-(biphenyl-3-yl)-1H-1,2,3-triazol-1-yl]-N-hydroxyheptanamide
-
Homo sapiens
7-{4-[4-(dimethylamino)phenyl]-1H-1,2,3-triazol-1-yl}-N-hydroxyheptanamide
-
Homo sapiens
LAQ-824
-
Homo sapiens
MS-275
-
Homo sapiens
N-hydroxy-5-(4-phenyl-1H-1,2,3-triazol-1-yl)pentanamide
-
Homo sapiens
N-hydroxy-6-(4-phenyl-1H-1,2,3-triazol-1-yl)hexanamide
-
Homo sapiens
N-hydroxy-6-[4-(2-methoxyphenyl)-1H-1,2,3-triazol-1-yl]hexanamide
-
Homo sapiens
N-hydroxy-6-[4-(3-methoxyphenyl)-1H-1,2,3-triazol-1-yl]hexanamide
-
Homo sapiens
N-hydroxy-6-[4-(3-methylphenyl)-1H-1,2,3-triazol-1-yl]hexanamide
-
Homo sapiens
N-hydroxy-6-[4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]hexanamide
-
Homo sapiens
N-hydroxy-6-[4-(4-methylphenyl)-1H-1,2,3-triazol-1-yl]hexanamide
-
Homo sapiens
N-hydroxy-6-[4-(6-methoxynaphthalen-2-yl)-1H-1,2,3-triazol-1-yl]hexanamide
-
Homo sapiens
N-hydroxy-6-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]hexanamide
-
Homo sapiens
N-hydroxy-6-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]hexanamide
-
Homo sapiens
N-hydroxy-6-[4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl]hexanamide
-
Homo sapiens
N-hydroxy-6-[4-(quinolin-2-yl)-1H-1,2,3-triazol-1-yl]hexanamide
-
Homo sapiens
N-hydroxy-6-[4-(quinolin-7-yl)-1H-1,2,3-triazol-1-yl]hexanamide
-
Homo sapiens
N-hydroxy-6-[4-(thiophen-2-yl)-1H-1,2,3-triazol-1-yl]hexanamide
-
Homo sapiens
N-hydroxy-6-{4-[4-(pyridin-4-yl)phenyl]-1H-1,2,3-triazol-1-yl}hexanamide
-
Homo sapiens
N-hydroxy-7-(4-phenyl-1H-1,2,3-triazol-1-yl)heptanamide
-
Homo sapiens
N-hydroxy-7-[4-(6-methoxynaphthalen-2-yl)-1H-1,2,3-triazol-1-yl]heptanamide
-
Homo sapiens
N-hydroxy-7-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]heptanamide
-
Homo sapiens
N-hydroxy-7-{4-[4-(pyridin-4-yl)phenyl]-1H-1,2,3-triazol-1-yl}heptanamide
-
Homo sapiens
sodium butyrate
-
Homo sapiens
suberoylanilide hydroxamic acid
-
Homo sapiens
trichostatin A
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
DU-145 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
HDAC
-
Homo sapiens
histone deacetylase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
activity assay at room temperature Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000018
-
-
Homo sapiens N-hydroxy-6-[4-(6-methoxynaphthalen-2-yl)-1H-1,2,3-triazol-1-yl]hexanamide
0.0000019
-
-
Homo sapiens 6-[4-(biphenyl-3-yl)-1H-1,2,3-triazol-1-yl]-N-hydroxyhexanamide
0.0000021
-
-
Homo sapiens N-hydroxy-6-[4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]hexanamide
0.0000021
-
-
Homo sapiens N-hydroxy-6-[4-(quinolin-2-yl)-1H-1,2,3-triazol-1-yl]hexanamide
0.0000023
-
-
Homo sapiens N-hydroxy-6-{4-[4-(pyridin-4-yl)phenyl]-1H-1,2,3-triazol-1-yl}hexanamide
0.0000043
-
-
Homo sapiens 6-{4-[4-(dimethylamino)phenyl]-1H-1,2,3-triazol-1-yl}-N-hydroxyhexanamide
0.000005
-
-
Homo sapiens trichostatin A
0.0000054
-
-
Homo sapiens 7-[4-(biphenyl-3-yl)-1H-1,2,3-triazol-1-yl]-N-hydroxyheptanamide
0.0000096
-
-
Homo sapiens N-hydroxy-7-(4-phenyl-1H-1,2,3-triazol-1-yl)heptanamide
0.0000139
-
-
Homo sapiens N-hydroxy-6-[4-(3-methoxyphenyl)-1H-1,2,3-triazol-1-yl]hexanamide
0.0000142
-
-
Homo sapiens N-hydroxy-6-(4-phenyl-1H-1,2,3-triazol-1-yl)hexanamide
0.0000153
-
-
Homo sapiens N-hydroxy-7-[4-(6-methoxynaphthalen-2-yl)-1H-1,2,3-triazol-1-yl]heptanamide
0.0000166
-
-
Homo sapiens N-hydroxy-7-{4-[4-(pyridin-4-yl)phenyl]-1H-1,2,3-triazol-1-yl}heptanamide
0.0000174
-
-
Homo sapiens N-hydroxy-6-[4-(3-methylphenyl)-1H-1,2,3-triazol-1-yl]hexanamide
0.0000239
-
-
Homo sapiens N-hydroxy-7-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]heptanamide
0.0000317
-
-
Homo sapiens N-hydroxy-6-[4-(thiophen-2-yl)-1H-1,2,3-triazol-1-yl]hexanamide
0.0000319
-
-
Homo sapiens N-hydroxy-6-[4-(3-methylphenyl)-1H-1,2,3-triazol-1-yl]hexanamide
0.0000434
-
-
Homo sapiens N-hydroxy-6-[4-(4-methylphenyl)-1H-1,2,3-triazol-1-yl]hexanamide
0.0000524
-
-
Homo sapiens 6-[4-(biphenyl-4-yl)-1H-1,2,3-triazol-1-yl]-N-hydroxyhexanamide
0.000065
-
-
Homo sapiens suberoylanilide hydroxamic acid
0.0000676
-
-
Homo sapiens N-hydroxy-6-[4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl]hexanamide
0.000076
-
-
Homo sapiens N-hydroxy-6-[4-(2-methoxyphenyl)-1H-1,2,3-triazol-1-yl]hexanamide
0.0001061
-
-
Homo sapiens 7-{4-[4-(dimethylamino)phenyl]-1H-1,2,3-triazol-1-yl}-N-hydroxyheptanamide
0.00011
-
-
Homo sapiens N-hydroxy-5-(4-phenyl-1H-1,2,3-triazol-1-yl)pentanamide
0.0001125
-
-
Homo sapiens N-hydroxy-6-[4-(pyridin-4-yl)-1H-1,2,3-triazol-1-yl]hexanamide
0.0001515
-
-
Homo sapiens N-hydroxy-6-[4-(quinolin-7-yl)-1H-1,2,3-triazol-1-yl]hexanamide
0.0001626
-
-
Homo sapiens 6-[4-(biphenyl-2-yl)-1H-1,2,3-triazol-1-yl]-N-hydroxyhexanamide
0.0002872
-
-
Homo sapiens N-hydroxy-6-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]hexanamide
0.0003159
-
-
Homo sapiens 6-[4-(2,6-dimethoxyphenyl)-1H-1,2,3-triazol-1-yl]-N-hydroxyhexanamide