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Literature summary for 3.5.1.98 extracted from
- Sulforaphane inhibits histone deacetylase activity in BPH-1, LnCaP and PC-3 prostate epithelial cells (2006), Carcinogenesis, 27, 811-819.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| sulforaphane | at 0.015 mM, 40, 30 and 40% inhibition of histone deacetylase activities in BPH-1, LnCaP and PC-3 prostate epithelial cells, resp. Inhibition is accompanied by a 50-100% increase in acetylated histones. BPH-1 cells treated with inhibitor show enhanced interaction of acetylated histone H4 with the promoter region of the P21 gene and the bax gene | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| BPH-1 cell | prostate epithelial cell | Homo sapiens | - |
| LNCaP cell | prostate epithelial cell | Homo sapiens | - |
| PC-3 cell | prostate epithelial cell | Homo sapiens | - |
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