Cloned (Comment) | Organism |
---|---|
stable expression in MCF-7 cell | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knock-down of isoform HDAC2 expression by small hairpin RNA inhibits cellular proliferation in a dose-dependent manner, which is also partly p53-dependent and induces cellular senescence. Knock-down enhances p53-dependent trans-repression and trans-activation of a subset of target genes. Enhancement is due to increased p53-DNA binding activity | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isoform HDAC2 | - |