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Literature summary for 3.5.1.98 extracted from
- Histone deacetylase 4 is required for TGFbeta 1-induced myofibroblastic differentiation (2007), Biochim. Biophys. Acta, 1773, 1572-1582.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | silencing of enzyme isoforms HDAC, HDAC6, and HDAC8 expression impairs transforming growth factor beta1-induced expression of smooth muscle alpha-actin. HDAC4 silencing is most efficient and also prevents transforming growth factor beta1-mediated morphological changes. Forced down-regulation of HDAC4 stimulates the expression of 5-TG-3-interacting factor and TGIF2 homeoproteins | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | isoform HDAC4 is an essential regulator of myofibroblastic differentiation | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fibroblast | - |
Homo sapiens | - |
| skin | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | isoform HDAC4 is an essential regulator of myofibroblastic differentiation | Homo sapiens | ? | - |
? | |
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Release 2023.1 (January 2023)
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