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Literature summary for 3.5.1.2 extracted from
- Structure-effect relationship in the down-regulation of glutaminase in cultured human cells by phenylarsenic compounds (2009), Toxicology, 258, 157-163.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| diphenylarsinic acid | the protein level of GAC significantly decrease in an concentration manner. The PAG activities are also decreased in parallel with the decrease in GAC | Homo sapiens |  |
| additional information | bis(diphenylarsine)oxide causes no siginficant changes in GAC levels and PAG activities. Methylated inorganic arsenics dimethylarsinic acid, dimethylarsinous acid, and phenyldimethylarsine oxide show no effects on GAC levels and PAG activities. And both glutathione-conjugated diphenylarsinic acid and triphenylarsine had no significant suppressive effects on the GAC levels and PAG activity | Homo sapiens | |
| phenylarsonic acid | causes a decrease in GAC levels | Homo sapiens | |
| phenylmethylarsinic acid | causes a decrease in GAC levels | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| Hep-G2 cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GAC | - |
Homo sapiens |
| glutaminase C | a splicing variant of the kidney-type glutaminase and has the enzyme activity of the phosphate-activated glutaminase | Homo sapiens |
| PAG | - |
Homo sapiens |
| phosphate-activated glutaminase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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