Literature summary for 3.5.1.2 extracted from

Suzuki, S.; Tanaka, T.; Poyurovsky, M.V.; Nagano, H.; Mayama, T.; Ohkubo, S.; Lokshin, M.; Hosokawa, H.; Nakayama, T.; Suzuki, Y.; Sugano, S.; Sato, E.; Nagao, T.; Yokote, K.; Tatsuno, I.; Prives, C.
Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species (2010), Proc. Natl. Acad. Sci. USA, 107, 7461-7466.

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Cloned(Commentary)

Cloned (Comment)	Organism
overexpression of GLS2 reduces the growth of tumor cells and colony formation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
GLS2	-	Homo sapiens
phosphate-activated glutaminase	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	GLS2 expression is reduced in liver tumors	down
Homo sapiens	is induced in response to DNA damage or oxidative stress in a p53-dependent manner, and p53 associates with the GLS promotor	up

General Information

General Information	Comment	Organism
physiological function	GLS2 probably controls the intracellular reactive oxygen species (ROS) and the apoptotic response fascilitating the ability of p53 to protect cells from accumulation of genomic damage and allows cells to survive after mild and repairable genotoxic stress	Homo sapiens

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Release 2023.1 (January 2023)