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Literature summary for 3.5.1.2 extracted from

  • Hartman, S.C.
    Glutaminases and gamma-glutamyltransferases (1971), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 4, 79-100.
No PubMed abstract available

Activating Compound

Activating Compound Comment Organism Structure
1,10-phenanthroline slight activation Escherichia coli
dithiothreitol slight activation Escherichia coli
EDTA slight activation Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
6-diazo-5-oxo-L-norleucine
-
Escherichia coli
Ag+
-
Escherichia coli
Cu2+
-
Escherichia coli
Hg2+ 0.1 mM, complete inhibition Escherichia coli
p-mercuribenzoate 0.1 mM, complete inhibition, presence of Gln prevents inhibition Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information effect of pH on Km-value Escherichia coli
0.42
-
Gln
-
Escherichia coli
2.9
-
Glu
-
Escherichia coli
3.3
-
gamma-glutamyl methylamide
-
Escherichia coli
10
-
gamma-thiomethyl glutamate
-
Escherichia coli
12
-
gamma-glutamyl hydrazide
-
Escherichia coli
23
-
gamma-thioethyl glutamate
-
Escherichia coli
50
-
gamma-ethyl glutamate
-
Escherichia coli
64
-
gamma-methyl glutamate
-
Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
production of significant amounts of enzyme only after the stage of rapid exponential growth
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Reaction

Reaction Comment Organism Reaction ID
L-glutamine + H2O = L-glutamate + NH3 mechanism Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
gamma-ethyl glutamate + H2O
-
Escherichia coli Glu + ethanol
-
?
gamma-ethyl glutamate + hydroxylamine
-
Escherichia coli gamma-glutamyl hydroxamate + ethanol
-
?
gamma-glutamyl-hydrazide + H2O
-
Escherichia coli Glu + hydroxyhydrazine
-
?
gamma-glutamyl-hydrazide + hydroxylamine
-
Escherichia coli Glu + hydroxyhydrazine
-
?
gamma-glutamyl-hydroxamate + H2O
-
Escherichia coli Glu + hydroxylamine
-
?
gamma-glutamyl-hydroxamate + hydroxylamine
-
Escherichia coli gamma-glutamyl hydroxamate + hydroxylamine
-
?
gamma-glutamyl-methoxyamide + H2O
-
Escherichia coli Glu + N-hydroxy-O-methylhydroxylamine
-
?
gamma-glutamyl-methoxyamide + hydroxylamine
-
Escherichia coli gamma-glutamyl hydroxamate + N-hydroxy-O-methylhydroxylamine
-
?
gamma-glutamyl-methylamide + H2O
-
Escherichia coli Glu + N-methylhydroxylamine
-
?
gamma-glutamyl-methylamide + hydroxylamine
-
Escherichia coli gamma-glutamyl hydroxamate + N-methylhydroxylamine
-
?
gamma-methyl glutamate + H2O
-
Escherichia coli Glu + methanol
-
r
gamma-methyl glutamate + hydroxylamine
-
Escherichia coli gamma-glutamyl hydroxamate + methanol
-
?
gamma-thioethyl glutamate + H2O
-
Escherichia coli Glu + thioethanol
-
?
gamma-thioethyl glutamate + hydroxylamine
-
Escherichia coli gamma-glutamyl hydroxamate + ?
-
?
gamma-thiomethyl glutamate + H2O
-
Escherichia coli Glu + thiomethanol
-
?
gamma-thiomethyl glutamate + hydroxylamine
-
Escherichia coli gamma-glutamyl hydroxamate + ?
-
?
Gln + H2O
-
Escherichia coli Glu + NH3
-
?
Glu + hydroxylamine
-
Escherichia coli gamma-glutamyl hydroxamate + H2O
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
additional information effect of pH on turnover number Escherichia coli
8
-
gamma-glutamyl methylamide
-
Escherichia coli
14
-
gamma-glutamyl hydrazide
-
Escherichia coli
36
-
gamma-ethyl glutamate
-
Escherichia coli
212
-
gamma-glutamyl-hydroxamate
-
Escherichia coli
296
-
gamma-glutamyl methoxyamide
-
Escherichia coli
300
-
gamma-thioethyl glutamate
-
Escherichia coli
645
-
gamma-methyl glutamate
-
Escherichia coli
1260
-
gamma-thiomethyl glutamate
-
Escherichia coli
1270
-
Gln
-
Escherichia coli
5080
-
Glu
-
Escherichia coli