Literature summary for 3.4.24.86 extracted from

Oikawa, H.; Maesawa, C.; Tatemichi, Y.; Nishinari, Y.; Nishiya, M.; Mizugai, H.; Ikeda, A.; Oikawa, K.; Takikawa, Y.; Masuda, T.
A disintegrin and metalloproteinase 17 (ADAM17) mediates epidermal growth factor receptor transactivation by angiotensin II on hepatic stellate cells (2014), Life Sci., 97, 137-144.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P78536	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
LI90 cell	hepatic stellate cell line	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	inhibitor TAPI-1, as well as antagonists of epidermal growth factor receptor and angiotensin II type-1 receptor, attenuate angiotensin II-induced epidermal growth factor receptor transactivation and proliferation of LI90 cells. Silencing of ADAM17 inhibits angiotensin II-induced secretion of mature amphiregulin in addition to epidermal growth factor receptor transactivation	Homo sapiens

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Release 2023.1 (January 2023)