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Literature summary for 3.4.24.86 extracted from

  • Breshears, L.M.; Schlievert, P.M.; Peterson, M.L.
    A disintegrin and metalloproteinase 17 (ADAM17) and epidermal growth factor receptor (EGFR) signaling drive the epithelial response to Staphylococcus aureus toxic shock syndrome toxin-1 (TSST-1) (2012), J. Biol. Chem., 287, 32578-32587.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.86

Organism

Organism UniProt Comment Textmining
Homo sapiens P78536
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Source Tissue

Source Tissue Comment Organism Textmining
HVEC cell ADAM17 proteolytic targets, amphiregulin, transforming growth factor (TGF-alpha), syndecan-1 (SDC1), and tumor necrosis factor receptor 1 (TNFR1), are shed from HVECs in response to staphylococcal superantigen toxic shock syndrome toxin TSST-1. ADAM17, but not related ADAM10, is required for amphiregulin, TGF-alpha, and TNFR1 shedding. Both ADAM10 and ADAM17 contribute to SDC1 shedding and IL-8 production by HVECs in response to TSST-1 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amphiregulin + H2O ADAM17, but not related ADAM10, is required for amphiregulin, TGF-alpha, and TNFR1 shedding Homo sapiens ?
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syndecan-1 + H2O both ADAM10 and ADAM17 contribute to SDC1 shedding Homo sapiens ?
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TGF-alpha + H2O ADAM17, but not related ADAM10, is required for amphiregulin, TGF-alpha, and TNFR1 shedding Homo sapiens ?
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tumor necrosis factor receptor 1 + H2O ADAM17, but not related ADAM10, is required for amphiregulin, TGF-alpha, and TNFR1 shedding Homo sapiens ?
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