Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GM6001 | poor inhibitive effectiveness on TACE | Homo sapiens | |
N-hydroxy-2-(2-oxo-2H-chromen-3-yl)acetamide | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | a zinc metalloprotease | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7-methoxycoumarin-4-yl)acetyl-Ser-Pro-Leu-Ala-Gln-Ala-Val-Arg-Ser-Ser-Ser-Arg-Lys(Dnp)-NH2 + H2O | - |
Homo sapiens | ? | - |
? | |
Dpa-SPLAQAVRSSSR-NH2 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ADAM-17 | - |
Homo sapiens |
TACE | - |
Homo sapiens |
TNF-alpha converting enzyme | - |
Homo sapiens |
tumour necrosis factor alpha-converting enzyme | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000175 | - |
in 25 mM Tris-HCl buffer, pH 9.0, 0.0025 mM ZnCl2 and 0.005% (v/v) Brij-35, at 37°C | Homo sapiens | N-hydroxy-2-(2-oxo-2H-chromen-3-yl)acetamide | |
0.000317 | - |
in 25 mM Tris-HCl buffer, pH 9, 0.0025 mM ZnCl2 and 0.005% (v/v) Brij-35, at 37°C | Homo sapiens | GM6001 |