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Literature summary for 3.4.24.86 extracted from

  • Kwak, H.I.; Mendoza, E.A.; Bayless, K.J.
    ADAM17 co-purifies with TIMP-3 and modulates endothelial invasion responses in three-dimensional collagen matrices (2009), Matrix Biol., 28, 470-479.
    View publication on PubMed
Search for more literature for 3.4.24.86

Localization

Localization Comment Organism GeneOntology No. Textmining
additional information ADAM17 localizes to bifurcations in invading sprouts Homo sapiens
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function silencing of ADAM17, but not ADAM15, expression using small interfering RNA interferes with endothelial cell invasion, resulting in decreased density of invading cells and decreased invasion distance. Stable endothelial cell lines expressing short hairpin RNA directed to ADAM17 are similarly inhibited. Expression of ADAM17 dominant negative mutant, but not ADAM10 or ADAM15 dominant negative mutants, decreases invasion density and distance. ADAM17 dominant negative mutant cells exhibit far greater numbers of protruding sprouts compared to control, suggesting an inability of extended processes to retract properly. Data suggest a role for ADAM17 in modulating endothelial sprouting events during angiogenesis Homo sapiens