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Literature summary for 3.4.24.86 extracted from

  • Hurst, L.A.; Bunning, R.A.; Couraud, P.O.; Romero, I.A.; Weksler, B.B.; Sharrack, B.; Woodroofe, M.N.
    Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment (2009), J. Neuroimmunol., 210, 108-112.
    View publication on PubMed

Application

Application Comment Organism
medicine increased expression and shedding of fractalkine by endothelial cells under pro-inflammatory conditions is not regulated by an increased activity of ADAM-17 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm ADAM-17 is located diffusely within the cell cytoplasm, and treatment with TNF-alpha does not alter the level of expression or the cytoplasmic distribution of ADAM-17 Homo sapiens 5737
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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Homo sapiens
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HCMEC/D3 cell ADAM-17, TIMP-3 and fractalkine are constitutively expressed Homo sapiens
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Expression

Organism Comment Expression
Homo sapiens ADAM-17 mRNA remains at control levels when treated with IL-1beta and IFN-gamma additional information
Homo sapiens ADAM-17 mRNA increases, but not significantly upon treatment with TNF -alpha and TGF-beta1 up

General Information

General Information Comment Organism
physiological function increased expression and shedding of fractalkine by endothelial cells under pro-inflammatory conditions is not regulated by an increased activity of ADAM-17 Homo sapiens