Application | Comment | Organism |
---|---|---|
medicine | increased expression and shedding of fractalkine by endothelial cells under pro-inflammatory conditions is not regulated by an increased activity of ADAM-17 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | ADAM-17 is located diffusely within the cell cytoplasm, and treatment with TNF-alpha does not alter the level of expression or the cytoplasmic distribution of ADAM-17 | Homo sapiens | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
HCMEC/D3 cell | ADAM-17, TIMP-3 and fractalkine are constitutively expressed | Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | ADAM-17 mRNA remains at control levels when treated with IL-1beta and IFN-gamma | additional information |
Homo sapiens | ADAM-17 mRNA increases, but not significantly upon treatment with TNF -alpha and TGF-beta1 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | increased expression and shedding of fractalkine by endothelial cells under pro-inflammatory conditions is not regulated by an increased activity of ADAM-17 | Homo sapiens |