Literature summary for 3.4.24.86 extracted from

Xu, J.; Liu, X.; Chen, J.; Zacharek, A.; Cui, X.; Savant-Bhonsale, S.; Chopp, M.; Liu, Z.
Cell-cell interaction promotes rat marrow stromal cell differentiation into endothelial cell via activation of TACE/TNF-alpha signaling (2010), Cell Transplant., 19, 43-53.

Search for more literature for 3.4.24.86

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-
endothelial cell	marrow stromal cell-brain microvascular endothelial cell contact coculture and indirect co-culture of marrow stromal cell and brain microvascular endothelial cell	Rattus norvegicus	-
stromal cell	marrow stromal cell-brain microvascular endothelial cell contact coculture and indirect co-culture of marrow stromal cell and brain microvascular endothelial cell	Rattus norvegicus	-

Expression

Organism	Comment	Expression
Rattus norvegicus	transcript levels of TACE and TNF-alpha as well as TACE protein expression are significantly upregulated in direct, but not in indirect coculture condition of marrow stromal cell and brain microvascular endothelial cell	up

General Information

General Information	Comment	Organism
physiological function	addition of human recombinant TACE promotes gene expression of endothelial specific markers including vWF, CD31, VE-cadherin, Flk-1 and Flt-1 in differentiating rat marrow stromal cells. Inhibition of TACE with TAPI-2 or inhibition of TNF-alpha with Etanercept attenuates endothelial differentiation of marrow stromal cells in direct co-culture condition with rain microvascular endothelial cells	Homo sapiens
physiological function	inhibition of TACE with TAPI-2 or inhibition of TNF-alpha with Etanercept attenuates endothelial differentiation of marrow stromal cells in the direct co-culture condition with rain microvascular endothelial cells	Rattus norvegicus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)