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Literature summary for 3.4.24.86 extracted from

  • Hiasa, M.; Abe, M.; Nakano, A.; Oda, A.; Amou, H.; Kido, S.; Takeuchi, K.; Kagawa, K.; Yata, K.; Hashimoto, T.; Ozaki, S.; Asaoka, K.; Tanaka, E.; Moriyama, K.; Matsumoto, T.
    GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme (TACE) (2009), Blood, 114, 4517-4526.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
granulocyte-macrophage colony-stimulating factor granulocyte-macrophage colony-stimulating factor GM-CSF and interleukin-4 in combination potently up-regulate tumor necrosis factor-alpha coverting enzyme TACE and activity in monocytes, causing ectodomain shedding of M-CSF receptor Homo sapiens
interleukin-4 granulocyte-macrophage colony-stimulating factor GM-CSF and interleukin-4 in combination potently up-regulate tumor necrosis factor-alpha coverting enzyme TACE and activity in monocytes, causing ectodomain shedding of M-CSF receptor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
peripheral blood mononuclear cell
-
 Homo sapiens
-
RPMI-8226 cell
-
 Homo sapiens
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U-266 cell
-
 Homo sapiens
-

Expression

Organism Comment Expression
Homo sapiens granulocyte-macrophage colony-stimulating factor GM-CSF and interleukin-4 in combination potently up-regulate tumor necrosis factor-alpha coverting enzyme TACE and activity in monocytes, causing ectodomain shedding of M-CSF receptor up

General Information

General Information Comment Organism
physiological function granulocyte-macrophage colony-stimulating factor GM-CSF and interleukin-4 in combination potently up-regulate tumor necrosis factor-alpha coverting enzyme TACE and activity in monocytes, causing ectodomain shedding of macrophage colony-stimulating factor M-CSF receptor, resulting in the disruption of its phosphorylation by M-CSF as well as the induction of osteoclastogenesis from monocytes by M-CSF and receptor activator of nuclear factor-kappaB RANK ligand. TACE inhibition robustly causes the resumption of the surface expression of M-CSF receptor on monocytes, facilitating M-CSF-mediated phosphorylation of M-CSF receptor and macrophage/osteoclast differentiation while impairing GM-CSF- and IL-4-mediated dendritic cell differentiation from monocytes Homo sapiens