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Literature summary for 3.4.24.86 extracted from

  • Hung, T.H.; Chen, S.F.; Hsieh, C.C.; Hsu, J.J.; Li, M.J.; Yeh, Y.L.; Hsieh, T.T.
    Tumor necrosis factor-alpha converting enzyme in the human placenta throughout gestation (2008), Reprod. Sci., 15, 195-209.
    View publication on PubMed
Search for more literature for 3.4.24.86

Application

Application Comment Organism
molecular biology results indicate that oxygen regulates the expression of TACE and TACE may be important for placental development during human pregnancy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
TAPI-1
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta by analyzing villous samples representing different gestational ages, it is shown that TACE is continuously expressed in the placentas throughout gestation and that the levels of TACE are positively correlated with the levels of TGF-alpha, heparin-binding epidermal growth factor-like growth factor, and amphiregulin Homo sapiens
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placental cell line Villous explant cultures or cytotrophoblastic cells are used. Preadministration of TACE inhibitor in villous explant cultures or transfection of cytotrophoblastic cells with TACE-specific small interference RNA decreases the shedding of heparin-binding epidermal growth factor-like growth factor and amphiregulin. Hypoxia (2% O2) causes an increase in the levels of TACE mRNA and protein in villous explants and primary cytotrophoblastic cells in vitro Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amphiregulin + H2O
-
 Homo sapiens ?
-
 ?
heparin-binding epidermal growth factor-like growth factor + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
TACE
-
 Homo sapiens