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Literature summary for 3.4.24.86 extracted from

  • Morange, P.E.; Tregouet, D.A.; Godefroy, T.; Saut, N.; Bickel, C.; Rupprecht, H.J.; Lackner, K.; Barbaux, S.; Poirier, O.; Peiretti, F.; Nalbone, G.; Juhan-Vague, I.; Blankenberg, S.; Tiret, L.
    Polymorphisms of the tumor necrosis factor-alpha (TNF) and the TNF-alpha converting enzyme (TACE/ADAM17) genes in relation to cardiovascular mortality: the AtheroGene study (2008), J. Mol. Med., 86, 1153-1161.
    View publication on PubMed
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Application

Application Comment Organism
medicine the relationship between ADAM17 and TNF polymorphisms, circulating levels of shed ADAM17 substrates, and cardiovascular risk in a prospective cohort of coronary artery disease patients is investigated. Five tag single-nucleotide polymorphisms (SNPs) of the ADAM17 gene as well as four previously described TNF SNPs are genotyped in the Atherogene Study composed of 1400 coronary artery disease patients among which 136 died from a cardiovascular cause. Soluble TNF, soluble TNF receptor 1, and soluble TNF receptor 2 concentrations are all significantly elevated in patients with future cardiovascular death, independently of other clinical/biological variables. The ADAM17-154A allele is found associated with a 14% increase of soluble TNF levels as compared to the -154C allele. Individuals carrying the 747Leu allele display a borderline increased risk of future cardiovascular death Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
soluble TNF + H2O
-
 Homo sapiens ?
-
 ?
soluble TNF receptor 1 + H2O
-
 Homo sapiens ?
-
 ?
soluble TNF receptor 2 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ADAM17
-
 Homo sapiens
TACE
-
 Homo sapiens