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Literature summary for 3.4.24.86 extracted from
- Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17 (2007), J. Thromb. Haemost., 5, 395-402.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| phorbol-12-myristate 13-acetate | - |
Homo sapiens |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | endothelial protein C receptor shedding is not influenced by DMSO, TIMP-1 or TIMP-2 | Homo sapiens | |
| TNF-alpha proteinase inhibitor | 0.00005 mM | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| endothelial protein C receptor + H2O | - |
Homo sapiens | ? | - |
? | |
| proTNF-alpha + H2O | - |
Homo sapiens | soluble TNF-alpha | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADAM17 | - |
Homo sapiens |
| TACE | - |
Homo sapiens |
| tumor necrosis factor-alpha converting enzyme | - |
Homo sapiens |
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