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Literature summary for 3.4.24.86 extracted from

  • Duan, J.J.; Chen, L.; Lu, Z.; Xue, C.; Liu, R.; Covington, M.B.; Qian, M.; Wasserman, Z.R.; Vaddi, K.; Christ, D.D.; Trzaskos, J.M.; Newton, R.C.; Decicco, C.P.
    Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 241-246.
    View publication on PubMed
Search for more literature for 3.4.24.86

Inhibitors

Inhibitors Comment Organism Structure
(3R,4R)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]tetrahydro-2H-pyran-3-carboxamide
-
 Sus scrofa
(3R,4S)-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
-
 Sus scrofa
(3S,4R)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-3-carboxamide
-
 Sus scrofa
(3S,4S)-1-tert-butyl-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
-
 Sus scrofa
(3S,4S)-1-[2-(dimethylamino)ethyl]-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
-
 Sus scrofa
(3S,4S)-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
-
 Sus scrofa
(3S,4S)-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]tetrahydro-2H-pyran-4-carboxamide
-
 Sus scrofa
2,6-anhydro-3,4,5-trideoxy-1-(hydroxyamino)-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-D-threo-hexose
-
 Sus scrofa
N-[(1R,2S)-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
 Sus scrofa
N-[(1S,2R)-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
 Sus scrofa
N-[2-(hydroxycarbamoyl)cyclobutyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
-
 Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Synonyms

Synonyms Comment Organism
TACE
-
 Sus scrofa
tumor necrosis factor alpha-converting enzyme
-
 Sus scrofa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000001
-
-
 Sus scrofa (3R,4R)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]tetrahydro-2H-pyran-3-carboxamide
0.000001
-
-
 Sus scrofa (3S,4S)-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
0.000001
-
-
 Sus scrofa N-[(1S,2R)-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
0.000001
-
-
 Sus scrofa N-[2-(hydroxycarbamoyl)cyclobutyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide
0.000001
-
 IC50 below 0.000001 mM Sus scrofa (3R,4S)-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
0.000001
-
 IC50 below 0.000001 mM Sus scrofa (3S,4S)-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]tetrahydro-2H-pyran-4-carboxamide
0.000002
-
-
 Sus scrofa (3S,4S)-1-[2-(dimethylamino)ethyl]-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
0.000002
-
-
 Sus scrofa (3S,4S)-1-tert-butyl-N-hydroxy-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-4-carboxamide
0.000003
-
-
 Sus scrofa 2,6-anhydro-3,4,5-trideoxy-1-(hydroxyamino)-3-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]-D-threo-hexose
0.000024
-
-
 Sus scrofa (3S,4R)-N-hydroxy-4-[([4-[(2-methylquinolin-4-yl)methoxy]phenyl]carbonyl)amino]piperidine-3-carboxamide
0.0002
-
-
 Sus scrofa N-[(1R,2S)-2-(hydroxycarbamoyl)cyclopentyl]-4-[(2-methylquinolin-4-yl)methoxy]benzamide